• CAPRISA duo graduate with PhDs

    We congratulate CAPRISA’s Dr Anushka Naidoo and Dr Gugulethu Mzobe who graduated with PhDs at the University of KwaZulu-Natal’s Spring Graduation ceremony.

    Dr Anushka Naidoo, Senior Research Pharmacist at CAPRISA, was awarded a PhD in Pharmacology at UKZN’s Spring graduation. Her study, entitled: “Moxifloxacin, Pharmacokinetics (PK-PD) in the treatment of drug susceptible Tuberculo-sis”, investigated if a clinically significant drug interaction that may affect drug expo-sure, exists between moxifloxacin and tuber-culosis drug rifampicin or antiretroviral drugs in TB-HIV coinfected patients enrolled in a clinical trial at CAPRISA. She also studied the effects of pharmacogenetic variation in genes coding of drug metabolising and drug transporter enzymes on moxifloxacin con-centrations in African patients.

    Dr Gugulethu Mzobe, a postdoctoral Research Fellow at CAPRISA, was awarded a PhD in Medical Microbiology. Her thesis examined temporal gene expression of Chla-mydia trachomatis in keratinocytes at 37°C.Her study confirms that mid-and-late cy-cle chlamydial gene expression levels aredifferent to the published research conduct-ed in HeLa cells at 37°C and that tempera-ture has an effect on the level of Chlamydialgene expression when grown in keratino-cytes. Her study also showed that two hourspost infection, chlamydia retains its elemen-tary body (EB)structural conformation inkeratinocytes at 37°C, and that L2 referencestrain 434 is different from the clinical L2US151 as indicated by the difference in thegene expression pattern.

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Centre for the AIDS Programme of Research in South Africa

CAPRISA was created in 2001 and formally established in 2002 under the NIH-funded Comprehensive International Program of Research on AIDS (CIPRA) by five partner institutions; University of KwaZulu-Natal, University of Cape Town, University of Western Cape, National Institute for Communicable Diseases, and Columbia University in New York. CAPRISA is a designated UNAIDS Collaborating Centre for HIV Prevention Research. The main goal of CAPRISA is to undertake globally relevant and locally responsive research that contributes to understanding HIV pathogenesis, prevention and epidemiology as well as the links between tuberculosis and AIDS care.