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  • CAPRISA post-doc Fellow to pursue antibody study

    Dr Gugulethu Mzobe, a postdoctoral research fellow at CAPRISA, was awarded a research grant from the Poliomyelitis Research Foundation [PRF] for a three-year period. 

         Mzobe who is under the mentorship of CAPRISA scientist Dr Sinaye Ngcapu in the Mucosal Immunology Laboratory will conduct research on the use of an ex vivo  human cervical explant model to explore the HIV prevention capabilities of CAP256-VRC26.25LS on its own and in combination with VRC07-523LS or PGT121. This study could help to explain the “key biological factors mediating effective antibody blocking of HIV-1 infection in human mucosal tissue,” explained Mzobe.

         This may have important “implications for bNAbs as a viable alternative to ARV-based HIV prevention,” she said.

     

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Centre for the AIDS Programme of Research in South Africa

CAPRISA was created in 2001 and formally established in 2002 under the NIH-funded Comprehensive International Program of Research on AIDS (CIPRA) by five partner institutions; University of KwaZulu-Natal, University of Cape Town, University of Western Cape, National Institute for Communicable Diseases, and Columbia University in New York. CAPRISA is a designated UNAIDS Collaborating Centre for HIV Prevention Research. The main goal of CAPRISA is to undertake globally relevant and locally responsive research that contributes to understanding HIV pathogenesis, prevention and epidemiology as well as the links between tuberculosis and AIDS care.