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STUDY Abbreviated title Title PI Type of study
    ONGOING    
CAP 011 IMPRESS Improving retreatment success Dr Nesri Padayatchi RCT
CAP 013 SUTHI Addressing challenges in scaling up TB and HIV Treatment integration in Public Health settings in South Africa Dr Kogie Naidoo RCT
CAP 020 InDEX Effectiveness of indivualized XDR-TB treatment study; a strategy to improve treatment outcomes in patients with XDR TB Dr Nesri Padayatchi/ Dr Kogie Naidoo RCT
CAP 055 ANC Survey (annual) Temporal trends in HIV infection in rural KwaZulu-Natal - implications for research and programmatic priority setting Prof Ayesha Kharsany survey
CAP 081 BLIX A Retrospective Chart Review of Patients With M(X)DR-TB Commenced On Linezolid Dr Nesri Padayatchi Chart Review
CAP 082 PrEP Implementation study Prospective study of HIV risk factors and prevention choices in young woman in KZN, South Africa Dr Leila Mansoor Cohort Study
CAP 083 STI study Changing the STI care model to reduce genital inflammation and HIV risk in South African women Dr Nigel Garrett/ Prof Anne Rompalo Cohort Study
CAP 084 PrEP Implementation study A demonstration project of daily, oral tenofovir disoproxil fumarate + emtricitabine
pre-exposure prophylaxis (PrEP) as part of sexual reproductive health services for
young women at high risk of acquiring HIV in KwaZulu-Natal: Informing policy and
practice for PrEP scale-up
Prof Quarraisha Abdool Karim Implementation Programme
CAP 085 CANS Identifying sources of HIV infection in adolescent girls in rural South Africa Prof Ayesha Kharsany Cohort Study
CAP 086 PRAXIS PRospective study of Adherence in M/XDR-TB Implementation Science Dr Nesri Padayatchi/ Dr Max O'Donnell Cohort Study
CAP 087 STREAM Study Point-of-care viral load testing to enable streamlined care and task shifting for chronic HIV care Dr Nigel Garrett/ Dr Paul Drain RCT
CAP 088 HPP study HIV incidence rates, socio-behavioural and biological HIV risk factors, HIV transmission rates and acceptability of prep during pregnancy and/or post-natally in KwaZulu-Natal Dr Daya Moodley Cohort Study
CAP 251 HIPSS HIV Incidence Provincial Surveillance System (HIPSS) Prof Ayesha Kharsany  Cohort Study
    COMPLETED    
CAP 001 START trial Starting Tuberculosis and Anti-Retroviral Therapy Trial: A Randomized Controlled Trial to Assess the Effect of Integrated Tuberculosis and HIV Care on the Incidence of AIDS-Defining Conditions or Mortality in participants Co-Infected with Tuberculosis and HIV. Prof Salim Abdool Karim  RCT
CAP 003 SAPIT trial A Study to compare three existing starting points of ART Initiation in HIV/TB co-infected patients  Prof Salim Abdool Karim RCT
CAP 004 Tenofovir gel trial Phase IIb Trial to Assess the Safety and Effectiveness of the Vaginal Microbicide 1% Tenofovir Gel for the Prevention of HIV Infection in Women in South Africa Prof Salim Abdool Karim/ Prof Quarraisha Abdool Karim RCT
CAP 005  TRuTH study TB Recurrence upon Treatment with HAART Dr Kogie Naidoo/ Prof Salim Abdool Karim Cohort Study
CAP 007 RHIVA Reducing HIV in Adolescents (RHIVA). A proof of concept cluster randomised controlled trial to evaluate the impact of a cash incentivised prevention intervention to reduce HIV infection in high school llearners in rural KwaZulu-Natal, South Africa Prof Quarraisha Abdool Karim RCT
CAP 008 Tenofovir gel implementation trial Open-Label Randomized Controlled Trial to Assess the Implementation Effectiveness and Safety of 1% Tenofovir Gel Provision through Family Planning Services in KwaZulu-Natal, South Africa Prof Quarraisha Abdool Karim/ Prof Salim Abdool Karim/ Dr Leila Mansoor Randomised,  Non-inferiority Open-label trial
CAP 009 TOAST Open Label Randomized Controlled Trial to Assess the Impact of prophylactic exposure to tenofovir gel on the efficacy of subsequent tenofovir-containing antiretroviral therapy on viral suppression Dr Nivashnee Naicker/ Prof Salim Abdool Karim/ Dr Anushka Naidoo RCT
CAP 050 Seroincidence study HIV Incidence Rates in Vulindlela and Durban:  A Prevention Preparedness Study (Vulindlela) Prof Quarraisha Abdool Karim Cohort Study
CAP 051 Seroincidence study HIV Incidence Rates in Vulindlela and Durban:  A Prevention Preparedness Study(eThekwini) Prof Quarraisha Abdool Karim Cohort Study
CAP 054 WiseBag study A pilot study to assess feasibility of utilizing a prototype Wisebag for enhancing measurement of gel use in CAPRISA 004  Dr Leila Mansoor/ Dr Tanuja Gengiah Pilot
CAP 056  XDR-TB & HIV / PROX A prospective study of treatment outcomes in extensively drug resistant tuberculosis (XDR Study) Dr Nesri Padayatchi/ Dr Max O'Donnell Cohort Study
CAP 057 Contraception Women’s understanding and practices regarding method choice for fertility control and/or disease prevention in KwaZulu-Natal Dr Cheryl Baxter Cohort Study
CAP 075 URLPAI Understanding socio-demographic and behavioral factors that result in patients seeking care with advanced stage HIV/AIDS disease in the context of free public sector access to Antiretroviral Therapy Dr Kogie Naidoo Cohort Study
CAP 078 HEPS Evaluation of HIV-specific Immunological and virological responses of HIV-1 multiply-exposed seronegative individuals Prof Salim Abdool Karim Cohort Study
CAP 104 Case Control (004) Microbicide Case Control Study to evaluate behavioural patterns of risk and gel use in a phase 2b trial Dr Kate McQueen/ Dr Francios van Loggenberg Nested case-control study
CAP 106 CAP 106 TFV-SHSR study CAPRISA 106 Tenofovir Gel Social and Health Systems Research Study Dr Sarah Dlamini/ Dr Kate MacQueen/ Dr Kristine Torjesen Social Science

Centre for the AIDS Programme of Research in South Africa

CAPRISA was created in 2001 and formally established in 2002 under the NIH-funded Comprehensive International Program of Research on AIDS (CIPRA) by five partner institutions; University of KwaZulu-Natal, University of Cape Town, University of Western Cape, National Institute for Communicable Diseases, and Columbia University in New York. CAPRISA is a designated UNAIDS Collaborating Centre for HIV Prevention Research. The main goal of CAPRISA is to undertake globally relevant and locally responsive research that contributes to understanding HIV pathogenesis, prevention and epidemiology as well as the links between tuberculosis and AIDS care.